Neugalin 50mg

Capsule
Pregabalin
ACME Laboratories Ltd

Other Strength:
- Neugalin 25mg
- Neugalin 75mg
- Neugalin 150mg

Alternative:
- Nervalin 50mg
- Pregaben 50mg
- Lyric 50mg
- Neurolin 50mg



Neugalin
DescriptionPregabalin is a structural derivative of the inhibitory neurotransmitter gamma aminobutyric acid (GABA), it does not bind directly to GABAA, GABAB and benzodiazepine receptor. Pregabalin selectively binds to the alpha-2delta subunit protein of voltage-gated calcium channels in various regions of central nervous system tissues. Pregabalin oral bioavailability is approximately 90% and it is well absorbed after oral administration.

CompositionNeugalin25 : Each capsule contains Pregabalin INN 25 mg.Neugalin50 : Each capsule contains Pregabalin INN 50 mg.Neugalin75 : Each capsule contains Pregabalin INN 75 mg.

Indications•Neuropathic pain from diabetic neuropathy.•Post herpetic neuralgia.•Fibromyalgia.•Adjunctive therapy in adults with partial seizures with or without secondary generalization.•Generalized anxiety disorder.

Dosage and AdministrationNeuropathic pain Initially 150 mg/day in 2-3 divided doses, may be increased if necessary after 3-7 days to 300 mg daily in 2 divided doses, The dose may be increased further if necessary after 7 days to maximum 600 mg daily in two divided doses .Post herpetic neuralgiaThe recommended dose is 75 to 150 mg two times a day, dosing should begin at 75 mg two times a day and may be increased to 300 mg/day within 1 week based on efficacy and tolerability. FibromyalgiaThe recommended dose of Pregabalin for fibromyalgia is 300 to 450 mg/day in two divided doses.Epilepsy Initially 150 mg daily in 2 divided doses, increased if necessary after 7 days to 300 mg daily in 2 divided doses, increased further if necessary after 7 days to maximum 600 mg daily in 2 divided doses.Generalized anxiety disorderInitially 150 mg daily in 2 divided doses, increased if necessary after 7 days to 300 mg in 2 divided doses, increased further if necessary after 7 days to maximum 600 mg daily in 2 divided doses.Or as directed by the physician.

ContraindicationsPregabalin is contraindicated in patients with known hypersensitivity to Pregabalin or any of its components.Side effectsThe most common side effects reported are tiredness, dizziness, headache, dry mouth, nausea, vomiting, constipation.Precautions Abrupt or rapid discontinuation may result in insomnia, nausea, headache, or diarrhea. Concomitant treatment with Pregabalin and a antidiabetic agent may lead to an additive effect on edema and weight gain. For patients with preexisting cardiac conditions, this may increase the risk of heart failure.Use in pregnancy and lactationPregnancy category C. It should be used during pregnancy only if the potential benefits justifies the potential risk to the fetus. Breast feeding is not recommended during treatment with Pregabalin.Pediatric use The safety and efficacy of pregabalin in pediatric patients have not been established.Drug interactionsInteractions may occur with opioids benzodiazepines, barbiturates, ethanol (alcohol), and other drugs that depress the central nervous system. Overdosage Overdose of up to 8000 mg has been reported. The most commonly reported adverse events in overdose are somnolence, confusional state, agitation and restlessness.



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